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Stopping Cetirizine Linked to Itch?

Q. I took the antihistamine cetirizine (generic Zyrtec) for two years for allergies. When I ran out a week ago, I broke out into an itchy rash on my arms and chest. At first I thought it was a food allergy.
By the third day I could not sleep because of the itch. I began to wonder if I was experiencing a withdrawal from cetirizine due to a histamine rebound.
I looked up Zyrtec withdrawal online and was astounded to find so many others having the same experience. Does the FDA ever require new drugs be tested for more than a few months to study the effects of sudden withdrawal? Why aren’t there warnings on this drug? This is now day 7 and I’m still itching like crazy.
A. We found no mention of itching associated with withdrawal from cetirizine (Zyrtec) in the official prescribing information. That said, we have heard from many other people that stopping this drug suddenly can trigger intense itching.
The FDA rarely requires companies to study potential withdrawal difficulties unless there is already a suspicion that this might be a problem.

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About the Author
Terry Graedon, PhD, is a medical anthropologist and co-host of The People’s Pharmacy radio show, co-author of The People’s Pharmacy syndicated newspaper columns and numerous books, and co-founder of The People’s Pharmacy website. Terry taught in the Duke University School of Nursing and was an adjunct assistant professor in the Department of Anthropology. She is a Fellow of the Society of Applied Anthropology. Terry is one of the country's leading authorities on the science behind folk remedies..
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