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Stopping Antidepressant Poses Challenge

Q. I have been taking the antidepressant Pristiq and wanted to get off it. But stopping really was uncomfortable, with shivers, high blood pressure, rapid heart rate and dizziness.
My doctor said I needed to go back on it because of my low serotonin levels. I am taking it again now and wondering how I can ever get off of this drug. Is there a natural supplement to support my serotonin levels?

A. Getting off antidepressants like Paxil (paroxetine), Pristiq (desvenlafaxine) or Zoloft (sertraline) may require patience and persistence. The withdrawal side effects you experienced are not uncommon and sometimes last for weeks. Other symptoms that have been reported after stopping such drugs include nausea, sweating, headache, dizziness and “brain zaps.”
If your doctor is willing, you might switch to a longer-acting antidepressant and taper off it gradually, as this reader did: “By switching to Prozac for about two months I was able to reverse the ‘brain zaps’ I had when stopping Effexor XR, and then I came off the Prozac slowly with no withdrawal symptoms.”
Several non-drug approaches to depression may be effective. We discuss them in our Guide to Dealing with Depression, which we are sending you. It also describes strategies for getting off antidepressants.

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About the Author
Terry Graedon, PhD, is a medical anthropologist and co-host of The People’s Pharmacy radio show, co-author of The People’s Pharmacy syndicated newspaper columns and numerous books, and co-founder of The People’s Pharmacy website. Terry taught in the Duke University School of Nursing and was an adjunct assistant professor in the Department of Anthropology. She is a Fellow of the Society of Applied Anthropology. Terry is one of the country's leading authorities on the science behind folk remedies..
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