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NSAIDs Can Cause Kidney Damage

Q. I read in your column that naproxen can cause kidney damage. I want to reinforce that warning. I lost my kidneys as a result of taking prescription strength naproxen in 1995. I took this anti-inflammatory drug off and on for three to six months.

I eventually needed a kidney transplant. I was lucky to get one in time. People must be informed that this kind of medicine can be dangerous. Many doctors prescribe these drugs without warning patients.

A. Over 20 million Americans use nonsteroidal anti-inflammatory drugs (NSAIDs) daily for arthritis and other pain problems. This class of medicine includes OTC ibuprofen and naproxen as well as a range of prescription drugs (celecoxib, diclofenac, etodolac, piroxicam, etc).

Side effects of such drugs include stomach upset, ulcers, high blood pressure, fluid retention, heart failure, skin rash, liver and kidney damage. Anyone with kidney impairment is far more likely to experience kidney toxicity on these drugs.

People in pain are caught in a dilemma. The most frequently prescribed pain medicine, NSAIDs, can cause a lot of damage. We offer a number of other options in our Guide to Alternatives for Arthritis.

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About the Author
Joe Graedon is a pharmacologist who has dedicated his career to making drug information understandable to consumers. His best-selling book, The People’s Pharmacy, was published in 1976 and led to a syndicated newspaper column, syndicated public radio show and web site. In 2006, Long Island University awarded him an honorary doctorate as “one of the country's leading drug experts for the consumer.”.
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