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How to Get Off Cymbalta

Q. Getting off Cymbalta is challenging but not impossible. I experienced light-headedness, dizziness, and “brain zaps.” These felt like being able to hear my eyes move. It sounded like the light sabers on Star Wars–very strange and disconcerting.

The key is to reduce the dosage very, very slowly. Take the capsules apart and begin by removing 5 or 10 of the tiny balls inside. Do this for a week or so, then slowly increase the amount you remove each week or two as you can tolerate it.

Your doctor may not be of any help. Mine wasn’t. He instructed me to wean off over a two to three week period and I almost lost my mind. I did it myself over about a YEAR or more.

A. We appreciate your detailed description of how you got off Cymbalta (duloxetine). The FDA does not require manufacturers of antidepressants such as citalopram, duloxetine, paroxetine, sertraline or venlafaxine to provide detailed instructions on gradual withdrawal. We think this is a serious oversight since “discontinuation syndrome” is common and challenging.

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About the Author
Joe Graedon is a pharmacologist who has dedicated his career to making drug information understandable to consumers. His best-selling book, The People’s Pharmacy, was published in 1976 and led to a syndicated newspaper column, syndicated public radio show and web site. In 2006, Long Island University awarded him an honorary doctorate as “one of the country's leading drug experts for the consumer.”.
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