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Strange Statin Side Effect: Testicular Pain

Q. My doctor prescribed atorvastatin (Lipitor) even though my cholesterol level was OK. He wanted it even lower.

Please alert your readers that although atorvastatin may work well to lower cholesterol, the cure may be worse than the disease. Not only did I suffer muscle pain, fatigue and leg cramps, but I thought my testicles were on fire. The pain was excruciating. I have spoken with others who experienced similar problems.

A. Many people report muscle or joint pain and fatigue while taking statin-type cholesterol-lowering medicines. Although the official prescribing information lists urinary tract infections as a possible side effect, there is no mention of testicular pain.

We found one case report in the medical literature, however (Annals of Pharmacotherapy, Jan. 2007). A 54-year-old man had achy testicles when he took lovastatin. He discontinued the drug and the pain disappeared. This experience was repeated with simvastatin and again with atorvastatin.

We discuss the pros and cons of statins and other ways to reduce cholesterol in our Guide to Cholesterol Control and Heart HealthThere is also research to suggest that statins are associated with lower testosterone levels and hypogonadism (Journal of Sexual Medicine, April, 2010).

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About the Author
Terry Graedon, PhD, is a medical anthropologist and co-host of The People’s Pharmacy radio show, co-author of The People’s Pharmacy syndicated newspaper columns and numerous books, and co-founder of The People’s Pharmacy website. Terry taught in the Duke University School of Nursing and was an adjunct assistant professor in the Department of Anthropology. She is a Fellow of the Society of Applied Anthropology. Terry is one of the country's leading authorities on the science behind folk remedies..
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