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Forget Vitamin D Supplements for Heart Disease

A meta-analysis in JAMA Cardiology shows no benefit from vitamin D supplements for heart disease. This is the latest in a series of such disappointments.

Vitamin D supplements disappoint again. That’s the conclusion of a meta-analysis published in JAMA Cardiology this week. The researchers noted that many epidemiological studies have linked low vitamin D levels to heart attacks, strokes, heart failure and other cardiovascular problems. Vitamin D is well known to be crucial for maintaining strong bones. Good levels of vitamin D seem to help protect children from air pollution. People with adequate levels of vitamin D seem to be less prone to cancer. Moreover, people with low blood levels of this vitamin are more susceptible to ulcerative colitis. But so far, supplements don’t seem to improve people’s health. This study of vitamin D supplements for heart disease did not change that perception (JAMA Cardiology, June 19, 2019).

How Did the Scientists Study Vitamin D Supplements for Heart Disease?

The researchers reviewed 21 randomized controlled trials involving vitamin D supplements for heart disease. These studies included more than 83,000 participants with an average age around 65. The trials had used a variety of doses and schedules. Altogether, however, the investigators found no indication that vitamin D supplements reduced the risk of cardiovascular events. 

Other Vitamin D Supplement Disappointments:

This comes on the heels of a large trial published in the New England Journal of Medicine last week. It demonstrated that people taking 4,000 IU daily of vitamin D3 were no less likely than those on placebo to develop type 2 diabetes.

Studies like this and many others over the years leave patients and doctors in a quandary. Low vitamin D levels are associated with multiple health conditions, but supplements appear to be ineffective for preventing such problems. This is not the first study to show that vitamin D supplements for heart disease are not effective. Unfortunately, it does not tell us how to ensure we have adequate levels of this crucial vitamin circulating in our bodies. 

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About the Author
Terry Graedon, PhD, is a medical anthropologist and co-host of The People’s Pharmacy radio show, co-author of The People’s Pharmacy syndicated newspaper columns and numerous books, and co-founder of The People’s Pharmacy website. Terry taught in the Duke University School of Nursing and was an adjunct assistant professor in the Department of Anthropology. She is a Fellow of the Society of Applied Anthropology. Terry is one of the country's leading authorities on the science behind folk remedies..
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Citations
  • Barbarawi M et al, "Vitamin D supplementation and cardiovascular disease risks in more than 83000 individuals in 21 randomized clinical trials: A meta-analysis." JAMA Cardiology, JUne 19, 2019. doi:10.1001/jamacardio.2019.1870
  • Pittas A et al, "Vitamin D supplementation and prevention of type 2 diabetes." New England Journal of Medicine, June 7, 2019. DOI: 10.1056/NEJMoa1900906
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