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Does Grape Juice Have Heart Healthy Benefits?

A reader who has embraced grape juice wonders if its cardiovascular benefits are imaginary. Science says they're real.

Over the years, readers have told us about using grape juice to manage a range of conditions. Some people mix it with plant pectin (Certo) to ease the pain of arthritic joints. Others report it soothes plantar fasciitis. We have even heard from people who use it to fight off colds. Could this popular beverage benefit the heart? Even more intriguing, might it help men with erectile dysfunction?

Might Grape Juice Counteract ED?

Concord grape juice has a long history as a vasodilator. Researchers have reported that it is rich in polyphenols, especially flavonoids that may reduce the risk of cardiovascular disease. Like cocoa flavanols, grape polyphenols can make blood vessels more flexible.

A new study analyzed data from the National Health and Nutrition Examination Survey (NHANES). According to the report, men who regularly consume grape juice (at least five times a week) were less likely to experience erectile dysfunction (Aging Male, Dec. 10, 2024). The study population included 1532 men, mostly in their 40s. There were 510 men with ED and 1022 individuals free of ED.

The researchers had to adjust for smoking, drinking, hypertension, diabetes and high cholesterol, since the prevalence was not the same between the two groups. After that statistical adjustment, the scientists found a lower risk for erectile dysfunction among the grape juice guzzlers. The authors admit, however, that grape juice is high in sugar. Even unsweetened grape juice contains fructose, so determining an amount that is enough but not too much will require future studies.

The cardiovascular benefits of grape juice have captured the attention of other readers.

Grape Juice and Cardiovascular Benefits:

Q. I was born in 1945 and was diagnosed as a baby with what at that time was called a heart murmur. I have had a racing heartbeat from time to time that lasts less than a minute. Sometimes my heart thumps hard once.

I have lived with this all my life. I am active and always have been. I have never fainted, had shortness of breath nor felt chest pain. It is just part of my life. My father died after having had five heart attacks in his seventies and my grandmother on my maternal side had a pacemaker and lived to be eighty-nine.

I read that grape juice helps make your blood less sticky, so for three years I have been drinking two eight-ounce glasses of grape juice every day. Recently I realized that I have less of these heart rate symptoms. As a bonus, the varicose vein in my left leg is less pronounced than it has been for years.

I take no prescription drugs, but I do take vitamins daily, try to eat right and I remain active. Am I imagining the benefits of grape juice?

What Does the Scientific Evidence Show?

A. There is evidence that “whole grape products” can lower blood pressure (Nutrition, Metabolism and Cardiovascular Diseases, Oct. 2023). Moreover, a study published in the journal Circulation (Sept. 7, 1999) demonstrated that when volunteers drank purple grape juice for two weeks, their blood vessels were more flexible and blood flow improved. We have not seen evidence that it can correct abnormal heart rhythms.

All the same, we do not think you are imagining the benefits of grape juice. An in-depth analysis in the journal Nutrients concluded that Concord grape juice provides cardiovascular benefits and may also be helpful against cancer and cognitive decline (Nutrients, Dec. 2015). Because it is naturally high in sugar, however, people with diabetes may need to exercise caution.

Citations
  • Wu L et al, "Exploring the association between consumption of different types of beverages and erectile dysfunction in US men: evidence from NHANES 2003–2004 data." Aging Male, Dec. 10, 2024. https://www.tandfonline.com/doi/full/10.1080/13685538.2024.2438821
  • Ashoori M et al, "The effect of whole grape products on blood pressure and vascular function: A systematic review and meta-analysis of randomized controlled trials." Nutrition, Metabolism and Cardiovascular Diseases, Oct. 2023. DOI: 10.1016/j.numecd.2023.05.001
  • Stein JH et al, "Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease." Circulation, Sept. 7, 1999. DOI: 10.1161/01.cir.100.10.1050
  • Blumberg JB et al, "Concord grape juice polyphenols and cardiovascular risk factors: Dose-response relationships." Nutrients, Dec. 2015. DOI: 10.3390/nu7125519
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About the Author
Terry Graedon, PhD, is a medical anthropologist and co-host of The People’s Pharmacy radio show, co-author of The People’s Pharmacy syndicated newspaper columns and numerous books, and co-founder of The People’s Pharmacy website. Terry taught in the Duke University School of Nursing and was an adjunct assistant professor in the Department of Anthropology. She is a Fellow of the Society of Applied Anthropology. Terry is one of the country's leading authorities on the science behind folk remedies..
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