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Cholesterol-Lowering Drug Is Linked to Liver Enzyme Elevation, Muscle Cramps and Nerve Pain

Q. Since starting on Lipitor about 10 years ago, I have developed restless leg syndrome, peripheral neuropathy in my feet, muscle cramps in my feet and legs and general muscle weakness. My liver enzymes have been elevated.

I don’t want to continue this medication, but the doctor says she doesn’t think it is the cause of my problems.

A. Statins such as atorvastatin (Lipitor), rosuvastatin (Crestor) and simvastatin (Zocor) can cause muscle cramps, muscle weakness and peripheral neuropathy (nerve pain). These cholesterol-lowering medications can also raise liver enzymes.

We are sending you our Guide to Cholesterol Control and Heart Health for more information on statin pros and cons and details on how to lower cholesterol without statins.

Recent research demonstrates that statin use increases the risk of developing diabetes (BMJ, online May 29, 2014) and can reduce physical activity (JAMA Internal Medicine, June 9, 2014). Less exercise is counterproductive for good health. Given the range of side effects you have experienced, we hope that your doctor will work with you to find healthier, more holistic ways to lower your risk of heart disease.

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About the Author
Terry Graedon, PhD, is a medical anthropologist and co-host of The People’s Pharmacy radio show, co-author of The People’s Pharmacy syndicated newspaper columns and numerous books, and co-founder of The People’s Pharmacy website. Terry taught in the Duke University School of Nursing and was an adjunct assistant professor in the Department of Anthropology. She is a Fellow of the Society of Applied Anthropology. Terry is one of the country's leading authorities on the science behind folk remedies..
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